Inherited NephroKitDx

Inherited NephroKitDx employs fully automated library preparation technology by enzymatic fragmentation and enrichment of regions of interest by hybridization with capture probes. Subsequently, massive sequencing is carried out on Illumina platforms.

• Compatible sequencers: NextSeq 500/550Dx System
• Number of reactions: 16
• Number of samples per run: Mid Output V2.5 Kit (300 cycles): 8 samples
• Sequencing: Paired-end (2×150 cycles)
• Type of sample: DNA from peripheral blood
• Amount of input DNA: 50-100 ng
• Target genes (529 genes): ACE, ACTB, ACTG1, ACTN4, ADAMTS13, ADAMTS9, ADCY10, AGT, AGTR1, AGXT, AHI1, ALG1, ALG8, ALG9, ALMS1, ALPL, AMER1, ANKFY1, ANKS6, ANLN, ANOS1, AP2S1, APOA1, APOA4, APOE, APOL1, APRT, AQP2, ARHGAP24, ARHGDIA, ARL13B, ARL3, ARL6, ARMC9, ATN1, ATP6V0A4, ATP6V1B1, ATP6V1C2, AVIL, AVP, AVPR2, B2M, B3GLCT, B9D1, B9D2, BBIP1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BICC1, BMP2, BMP4, BMPER, BNC2, BSCL2, BSND, C1QA, C1QB, C1QC, C3, C4A, C4B, C8ORF37, CA1, CA2, CASP10, CASR, CC2D2A, CCBE1, CCDC28B, CCL2, CCNQ, CD151, CD2AP, CD46, CD81, CD96, CDC42, CDC5L, CDC73, CDK10, CDK20, CDKN1C, CENPF, CEP104, CEP120, CEP164, CEP290, CEP41, CEP55, CEP83, CFB, CFH, CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, CFI, CFP, CHD1L, CHD7, CHRM3, CISD2, CIT, CLCN5, CLCN7, CLCNKA, CLCNKB, CLDN10, CLDN16, CLDN19, CNNM2, COL4A1, COL4A3, COL4A4, COL4A5, COL4A6, COPA, COQ2, COQ4, COQ6, COQ7, COQ8A, COQ8B, COQ9, CPLANE1, CPT1A, CRB2, CRKL, CSPP1, CTH, CTLA4, CTNS, CTU2, CUBN, CUL3, CYP24A1, DACH1, DACT1, DCDC2, DCHS1, DDX59, DGKE, DHCR7, DLC1, DMP1, DNAJB11, DNASE1, DSTYK, DVL1, DVL3, DYNC2H1, DYNC2LI1, DZIP1L, EGF, EHHADH, EMP2, ENPP1, EP300, ESCO2, ETFA, ETFB, ETFDH, ETV4, EXOC8, EYA1, FAH, FAM20A, FAN1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCL, FAS, FASLG, FAT1, FAT4, FCGR2A, FCGR3A, FGA, FGF10, FGF20, FGF23, FGFR2, FGFR3, FLCN, FLNA, FMN1, FN1, FOXI1, FOXP1, FRAS1, FREM1, FREM2, FUZ, FXYD2, G6PD, GANAB, GAPVD1, GATA3, GCM2, GDF11, GEMIN4, GLA, GLI3, GLIS2, GLIS3, GNA11, GPC3, GPHN, GREB1L, GRHPR, GRIP1, H19, HAAO, HAS2, HES7, HGD, HNF1A, HNF1B, HNF4A, HOGA1, HPRT1, HPSE2, HSD11B2, HSD17B4, HSPA9, IFT122, IFT140, IFT172, IFT27, IFT43, IFT46, IFT52, IFT74, IFT80, IFT81, INF2, INPP5E, INTU, INVS, IQCB1, IRF5, ITGA3, ITGA8, ITGAM, ITGB4, ITSN1, ITSN2, JAG1, JAM3, KANK1, KANK2, KANK4, KAT6B, KCNA1, KCNJ1, KCNJ10, KCNJ15, KCNJ16, KCTD1, KIAA0556, KIAA0586, KIAA0753, KIF14, KIF7, KLHL3, KMT2D, KYNU, LAGE3, LAMA5, LAMB2, LCAT, LMNA, LMX1B, LRIG2, LRP2, LRP4, LRP5, LYZ, LZTFL1, MAD2L2, MAFB, MAGED2, MAGI2, MAPKBP1, MBTPS2, MCM5, MKKS, MKS1, MMACHC, MNX1, MOCOS, MOCS1, MUC1, MYCN, MYH9, MYO1E, NAA10, NCAPG2, NDUFAF3, NDUFB8, NDUFS2, NEK1, NEK8, NEU1, NFIA, NIPBL, NOS1AP, NOTCH2, NPHP1, NPHP3, NPHP4, NPHS1, NPHS2, NR3C2, NRIP1, NSDHL, NUP107, NUP133, NUP160, NUP205, NUP85, NUP93, NXF5, NXN, OCRL, OFD1, OPLAH, OSGEP, PAX2, PAX8, PBX1, PCBD1, PCSK5, PDE6D, PDSS1, PDSS2, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PGM3, PHEX, PHGDH, PIBF1, PIEZO2, PIGN, PIGT, PKD1, PKD2, PKHD1, PLA2R1, PLCE1, PMM2, PODXL, PORCN, PRKCD, PRKCSH, PRPS1, PTEN, PTPN22, PTPRO, PUF60, RAD21, RAI1, RARRES1, REN, RERE, RET, RFWD3, RMND1, RNU4ATAC, ROBO2, ROR2, RPGRIP1L, RPL26, SALL1, SALL4, SARS2, SCARB2, SCNN1A, SCNN1B, SCNN1G, SDCCAG8, SEC61A1, SEC61B, SEC63, SEMA3E, SF3B4, SGPL1, SI, SIX1, SIX2, SIX5, SLC12A1, SLC12A2, SLC12A3, SLC12A7, SLC22A12, SLC26A1, SLC26A7, SLC2A2, SLC2A9, SLC34A1, SLC34A3, SLC36A2, SLC3A1, SLC41A1, SLC4A1, SLC4A2, SLC4A4, SLC5A1, SLC5A2, SLC6A19, SLC6A20, SLC7A7, SLC7A9, SLC9A3R1, SLIT2, SMARCAL1, SNRPB, SON, SOX11, SOX17, SPRY2, SRGAP1, STAT1, STAT4, STK11, STRA6, STS, SUFU, SYNPO, TBC1D24, TBC1D8B, TBX18, TBX4, TBXT, TCTN1, TCTN2, TCTN3, TFAP2A, THBD, THOC6, TMEM107, TMEM138, TMEM216, TMEM231, TMEM237, TMEM260, TMEM67, TNFSF4, TNIP1, TNS2, TNXB, TP53RK, TP63, TPRKB, TRAF3IP1, TRAP1, TREX1, TRIM32, TRIP11, TRPC6, TRPM6, TRPS1, TRRAP, TSC1, TSC2, TTC21B, TTC37, TTC8, TXNDC15, TXNL4A, UMOD, UPK3A, USP8, VANGL1, VANGL2, VDR, VHL, VIPAS39, VPS33B, VTN, WDPCP, WDR19, WDR34, WDR35, WDR60, WDR72, WDR73, WFS1, WNK1, WNK4, WNT3, WNT4, WNT5A, WNT7A, WT1, XDH, XPNPEP3, XPO5, XRCC2, XRCC4, ZAP70, ZIC3, ZMPSTE24, ZNF148, ZNF365, ZNF423

*The detection of CNVs is outside the scope of the CE/IVD marking.