Arrhythmias and sudden death without structural cardiopathy general panel [97 genes]

This panel includes those genes that can cause ventricular arrhythmias and sudden death as the first clinical manifestation. Therefore, channelopathies and some genes associated with cardiomyopathies are included, which could produce ventricular arrhythmias in a very early phase of the disease in which structural alterations may be minimal or absent, and the diagnosis of cardiomyopathy may be complicated.

The identification of a causal genetic variant that can explain the arrhythmic event is often the basis for the diagnosis of the underlying pathology. This is particularly important in cases of sudden death with a negative autopsy, where the results of the molecular autopsy guide the study, management, and follow-up of relatives and the detection of carriers of the variant who do not show any phenotypic manifestations.

This panel is mainly aimed at the diagnosis of not clearly defined phenotypes whose main manifestation are ventricular arrhythmias, such as cases of idiopathic ventricular fibrillation, cardiorespiratory arrest without structural alterations, or sudden death with a negative autopsy.