It allows the detection of large deletions and duplications, not punctual mutations.
Hereditary disorder. This involves muscle weakness, which worsens quickly.
Causes: Duchenne muscular dystrophy is a form of muscular dystrophy that gets worse quickly. Other muscular dystrophies (including Becker muscular dystrophy) worsen much more slowly.
Duchenne muscular dystrophy is caused by a defective gene for dystrophin (a protein in muscles). However, it often occurs in people with families with no known history of this condition.
The condition most often affects children because of the way the disease is inherited. Sons of women who are carriers of the disease (women with a defective chromosome, but who do not have symptoms) each have a 50% chance of having the disease, and daughters each have a 50% chance of being carriers. On very rare occasions, a woman may be affected by the disease.
Duchenne muscular dystrophy occurs in approximately 1 in 3,600 males. Because it is an inherited disorder, risks include a family history of Duchenne muscular dystrophy.