It is a genetic disorder that affects the skin, brain and nervous system, kidneys, heart, and lungs. The condition can also cause tumors to grow in the brain. These tumors have the appearance of a tuber or root.
Tuberous sclerosis is a genetic condition. Changes (mutations) in one of two genes, TSC1 and TSC2, are responsible for most cases.
It is only necessary for one of the parents to transmit the mutation for her child to acquire the disease. However, most cases are due to new mutations. In most cases, there is no family history of the disease.
This condition is one of a group of diseases called neurocutaneous syndromes. There is involvement of both the skin and the central nervous system (brain and spinal cord).
There are no known risk factors beyond having a parent with tuberous sclerosis. In that case, each child has a 50% chance of inheriting the disease.