Anita Harding’s landmark description of paraparesis distinguishes pure and complicated forms (Harding, 1983). Pure forms present isolated pyramidal signs such as spasticity, hyperreflexia, Babinski sign and motor deficits, which may be associated with sphincter disorders and alteration of deep sensitivity. Complicated forms include various clinical entities that combine spastic paraparesis with other neurological/non-neurological signs such as cerebellar ataxia, optic atrophy, retinitis pigmentosa, narrowing of the corpus callosum, neuropathy or epilepsy, among others.
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