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X-linked dominant inheritance
What is X-linked dominant inheritance pattern?
X-linked dominant inheritance means that the altered allele is dominant, so only one allele is sufficient for disease expression, and that the affected gene is located on the X chromosome. X-linked dominant disorders are usually more common in women, who have two X chromosomes, than men, who have one X and one Y chromosome, because they can inherit the mutated allele from either affected parent. If a woman is affected, there is a 50% chance that she passes the mutated allele to each of her children, regardless of their gender, who would then develop the X-linked disorder that runs in the family. If a man is affected, he will pass the mutated allele (and the disease) to all of his daughters but none of his sons.