MODY-type diabetes, of autosomal dominant transmission, is responsible for approximately 1-2% of all causes of diabetes. The diagnosis is usually made before the age of 35 and, unlike type 1 diabetes, it does not usually require insulin treatment. Furthermore, they do not present autoantibodies against pancreatic islets or develop ketoacidosis, while it is common to find evidence of endogenous insulin secretion after the honeymoon period (3-5 years from the onset of diabetes). Unlike type 2 diabetes, it is not usually associated with obesity or acanthosis nigricans. The genetic study is useful for the adequate management of the disease and to establish the associated prognosis (predictive value) and the differential diagnosis with other more common forms of diabetes. Responsible mutations are identified in more than 90% of cases in which there is clear suspicion of this disease. Some forms of the disease also cause alterations in lipid metabolism. The risk of premature atherosclerotic disease is increased in patients with MODY-type diabetes who do not receive timely treatment.
Through ClientSite you can filter variants and download your reports