This panel addresses autoinflammatory diseases characterized by febrile episodes of non-infectious origin as a usual manifestation. They include entities such as familial Mediterranean fever, familial cold urticaria, familial periodic fever, or Majeed syndrome, among others. The genes included in this panel constitute important modulators of innate immunity, intervening in various processes such as the production of inflammasomes, apoptosis , TNF or NF-kappaB-mediated signaling pathways.
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