Hereditary prostate cancer [17 genes]

Prostate cancer is a clinically and genetically heterogeneous disease with hereditary factors that are estimated to represent between 40-50% of cases, which include rare to medium high penetrance genetic variants and common low penetrance genetic variants. In particular, it has been demonstrated that HOXB13 and BRCA2 mutations increase the risk of prostate cancer. Mutations in BRCA2 would be responsible for 1-2% of early prostate tumors, conferring a higher risk of suffering prostate cancer at earlier ages (<65 years). Other syndromes associated with a higher risk of prostate cancer exist, among which Lynch syndrome stands out.

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Steps to follow

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1. Download & fill out

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2. Sample collection

Three sample types: saliva, peripheral blood or genomic DNA

3. Pack the sample

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4. Send the sample & the request

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5. Result: the report

Via: e-mail and/or through the customer portal

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Hereditary prostate cancer

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Technique: NGS capture panel

Turnaround time (TAT): 15 days

Ref. S-202211925

Hereditary prostate cancer: View panel

The genetic study can help carry out a correct differential diagnosis of the pathology and, therefore, not only guide the treatment but also provide a better prognosis approximation. Our recommendation includes a panel of multiple genes taking into account the different syndromes associated with both hereditary prostate cancer and hereditary renal cancer.

  • ATM
  • BRCA1
  • BRCA2
  • BRIP1
  • CHEK2
  • EPCAM
  • FAM175A
  • HOXB13
  • MLH1
  • MSH2
  • MSH6
  • NBN
  • PALB2
  • PMS2
  • RAD51C
  • RAD51D
  • TP53

Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines.
Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases.
* Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.