Hereditary melanoma [14 genes]
The gene that is more commonly affected in a predisposition towards melanoma is CDKN2A, which is implicated in 20-40% of familial cases. These alterations can be associated with Familial melanoma syndrome and pancreatic cancer. Other less common predisposing genes, but that are associated with a high risk of hereditary melanoma and other cancers are CDK4, POT1, BAP1, and MITF.
Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines.
Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases.
* Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.